i.        Lupus General

Lupus, an autoimmune disease, happens when the immune system attacks its tissues, causing inflammation, swelling, pain, and damage. Many people with active lupus feel ill in general and complain of fever, weight loss, and fatigue. People with lupus also develop specific problems when the immune system attacks a particular organ or area in the body.

The following areas of the body can be affected by lupus: skin, joints, kidneys, blood, brain and spinal cord, and heart and lungs. Symptoms of lupus differ from one person to another. Some people have just a few symptoms, while others have many. Some of the more common syptoms include: achy joints, unexplained fever, swollen joints, prolonged or extreme fatigue, skin rash, ankle swelling, pain in the chest when breathing deeply, hair loss, sensitivity to the sun, seizures, mouth or nose sores, and pale or purple fingers or toes from cold or stress.

Lupus Overview, WebMD,

ii.        Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease that has protean manifestations and follows a relapsing and remitting course. SLE is a chronic autoimmune disease that can affect almost any organ system; thus, its presentation and course are highly variable, ranging from indolent to fulminant. Patients may present with any of the following manifestations: Constitutional (fatigue, fever, arthralgia, weight changes), Musculoskeletal (arthralgia, arthropathy, myalgia, frank arthritis, avascular necrosis), Dermatologic (malar rash, photosensitivity, discoid lupus), Renal (acute or chronic renal failure, acute nephritic disease), Neuropsychiatric (seizure, psychosis), Pulmonary (pleurisy, pleural effusion, pneumonitis, pulmonary hypertension, interstitial lung disease), Gastrointestinal (nausea, dyspepsia, abdominal pain), Cardiac (pericarditis, myocarditis), Hematologic (cytopenias such as leukopenia, lymphopenia, anemia, or thrombocytopenia).

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