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Advanced Systolic Heart Failure

Heart failure with reduced ejection fraction (HFrEF) happens when the left side of the heart does not pump blood out to the body as well as normal. It is called systolic heart failure, because the left ventricle does not squeeze forcefully enough during systole, which is the phase of the heartbeat when the heart pumps blood. Systolic heart failure leads to progressive left ventricular impairment, has a poor prognosis and negatively affects the patient’s quality of life, especially when the disease advances to the point where it causes refractory symptoms.

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